Firstly, may I just state that Senator Isakson is spewing pure fiction. The H-1B Visa is called the outsourcing Visa by Indian offshore outsourcers because they are dependent on guest worker Visas to facilitate training of their staff by U.S. workers (who then get fired), and technology transfer. There also is no worker shortage whatsoever of U.S. citizens in these occupational areas. The idea that somehow firing US workers, denying US workers a career and opportunity creates jobs is pure corporate lobbyist spin and is Fictional Employment Theory.
Senator Isakson is also completely wrong on what kinds of jobs are being offshore outsourced. Some of the most advanced, high skilled jobs are going offshore just as Alan Blinder predicted in his research.